منابع مشابه
Why highly expressed proteins evolve slowly.
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that have remained unexplained. Here, we hypothesize that selection to reduce the burden of protein misfolding will favor protein sequences with increased robustness to translational missense errors. Pressu...
متن کاملDo essential genes evolve slowly?
Approximately two thirds of all knockouts of individual mouse genes give rise to viable fertile mice. These genes have thus been termed 'non-essential' in contrast to 'essential' genes, the knockouts of which result in death or infertility. Although non-essential genes are likely to be under selection that favours sequence conservation [1], it is predicted that they are less subject to such sta...
متن کاملWhy Does BitTorrent Work So Well?
BitTorrent (BT) is currently the most popular file-sharing peer-to-peer (P2P) clients [1]. Several reports have shown that it accounts for the majority of peer-to-peer traffic, up to one third of the global Internet traffic. However, leaving the media attention aside for one moment, we ask the question: Why does BT work so well? BT attempts to build robustness to freeloading (i.e. downloading w...
متن کاملHighly expressed genes in yeast evolve slowly.
tion of these findings is that proteins expressed in many The dataset used in this article consists of the remtissues interact with a greater number of molecules and nants of the ancient genome duplication including 376 may also have to function under widely changing cellugene pairs organized into 55 gene clusters (Wolfe and lar conditions. Hence, high pleiotropic constraints on Shields 1997). ...
متن کاملDifferential requirements for mRNA folding partially explain why highly expressed proteins evolve slowly.
The cause of the tremendous among-protein variation in the rate of sequence evolution is a central subject of molecular evolution. Expression level has been identified as a leading determinant of this variation among genes encoded in the same genome, but the underlying mechanisms are not fully understood. We here propose and demonstrate that a requirement for stronger folding of more abundant m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Integrative and Comparative Biology
سال: 2019
ISSN: 1540-7063,1557-7023
DOI: 10.1093/icb/icz099